Polycystic kidney diseaseDefinition:
Polycystic kidney disease is a kidney disorder passed down through families in which many cysts form in the kidneys, causing them to become enlarged.
Cysts - kidneys; Kidney - polycystic; Autosomal dominant polycystic kidney disease; ADPKD
Causes, incidence, and risk factors:
Polycystic kidney disease (PKD) is passed down through families (inherited), usually as an autosomal dominant trait. If one parent carries the gene, the children have a 50% chance of developing the disorder.
Autosomal dominant PKD occurs in both children and adults, but it is much more common in adults. Symptoms often do not appear until middle age. It affects nearly 1 in 1,000 Americans. The actual number may be more, because some people do not have symptoms.
An autosomal recessive form of PKD also exists. It appears in infancy or childhood. This form is much less common than autosomal dominant PKS, but it tends to be very serious and gets worse quickly. It can cause serious lung and liver disease, end-stage kidney disease, and it usually causes death in infancy or childhood.
Persons with PKD have many clusters of cysts in the kidneys. What exactly triggers the cysts to form is unknown.
PKD is associated with the following conditions:
As many as half of people with PKD have cysts on the liver. A family history of PKD increases your risk for the condition.
Other symptoms that may occur with this disease include:
Signs and tests:
An examination may show:
Tests that may be done include:
People with a personal or family history of PKD should be tested to determine if cerebral aneurysms are causing headaches.
Polycystic kidney disease and cysts on the liver or other organs may be found with the following tests:
If several members of your family have PKD, genetic tests can be done to determine whether you carry the PKD gene.
The goal of treatment is to control symptoms and prevent complications. High blood pressure may be hard to control, but controlling it is the most important part of treatment.
Treatment may include:
- Blood pressure medicines
- Low-salt diet
Any urinary tract infection should be treated quickly with antibiotics.
Cysts that are painful, infected, bleeding, or causing a blockage may need to be drained. There are usually too many cysts to make it practical to remove each cyst.
Surgery to remove one or both kidneys may be needed. Treatments for end-stage kidney disease may include dialysis or a kidney transplant.
You can often ease the stress of an illness by joining a support group where members share common experiences and problems.
See: Kidney disease - support group
The disease gets worse slowly. Eventually it leads to end-stage kidney failure . It is also associated with liver disease , including infection of liver cysts.
Medical treatment may relieve symptoms for many years.
People with PKD who don't have other diseases may be good candidates for a kidney transplant.
Calling your health care provider:
Call your health care provider if:
- You have symptoms of PKD
- You have a family history of polycystic kidney disease or related disorders and you are planning to have children (you may want to have genetic counseling)
Currently, no treatment can prevent the cysts from forming or enlarging.
Amaout MA. Cystic kidney diseases. In: Goldman L, Ausiello D, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 128.
Porter CC, Avner Ed. Anatomic abnormalities associated with hematuria. In: Kliegman RM, Stanton BF, St. Geme JW III, Schor NF, Behrman RE, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 515.
Torres VE, Grantham JJ. Cystic diseases of the kidney. In: Brenner BM, ed. Brenner and Rector's the Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 41.